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KMID : 0351819940350040411
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Kyunpook University Medical Journal
1994 Volume.35 No. 4 p.411 ~ p.418
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Effect of Lipopolysaccharide on the Phenylephrine-induced Contraction in the Isolated Aorta of Spontaneously Hypertensive Rat and Wistar-Kyoto Rat
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Han Hyung-Soo
Sung Young-Ho
Kim Choong-Young
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Abstract
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To compare the lipopolysaccharide(LPS)-induced expression of inducihle nitric oxide synthase in the aorta of hypertensive and normotensive rat model we evaluated the impairment of phenylephrine -induced contraction in isolated aorta of spontaneously hypertensive rat(SHR) and Wistar-Kyoto rat(WKY).
LPS (100nnjml)-treatment impaired phenylephrine(10-´~I)-induced contraction in denuded aorta of SHR but not in denuded aorta of WKY. Similar degree of impairment of phenylephrine-induced contraction ~as shown in endothelium intact aorta of SHR with or wiChout LPS-treatment. In intact aorta of ~Vh~~ LPS had no effect on the phenylephrine-induced contraction.
These results suggest that LPS-induced inducible nitric oxide synthase expression is more promi nent ir; SHR than ~~Vh~" and contraction inhibiting factor may he present in endothelial cells of SHR.
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KEYWORD
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lipopolysaccharide, contractility, inducible nitric oxide synthase
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